Dr said ihave lupus. what does all of this mean my ana direct was + my anti dna 48 what does all this mean?

See details: Lupus is an autoimmune disease with many possible clinical manifestations i see you are already on Plaquenil (hydroxychloroquine) and Methotrexate which is often a very effective combination. The best thing you can do is by under the care of a rheumatologist and stay on your meds. It is always better to be preemptive with this disease.