A member asked:

With a family history of lupus and 7 out of 11 symtoms, can you still have lupus if after 2 positive ana and anti dna you have a negitive result?

5 doctors weighed in across 3 answers
Dr. Thomas Namey answered

Specializes in Rheumatology

Are you on treatment: If on treatment, dna-ds antibody titers can bnormalize. You would be considered "in remission, " but because you are on rx. If I have patients with disease sx and positive serologies, i would place them on plaquenyl. Tests can normalize, even with this simple rx! also, immune disease activity can remit on its own!

Answered 12/10/2013

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No: Anti da-dna and or anti smith antibody need to be positive to make the diagnosis, .

Answered 3/18/2013

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Yes: I agree with dr. Namey on this issue. I would not disregard the previously positive tests even if the current studies are negative. Have you seen a rheumatologist?

Answered 3/23/2013

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