After 5 da. bactrim for actinobacter-er for chest-neg. er md refused bactrim-off 2 da. given cipro (ciprofloxacin) after bad rxn to doubled bactrim. now not improving-did bug become resistant? new culture nec.?

No: Does not become resistant that fast. Really need more information . Need to see the original ua. You may have a complication . May need another ua.

Resistance possible: Acinetibacter resistance could be occur when taking an antibiotic and not reaching therapeutic dose or discontinuing a medication before completing it. Some bacteria require double coverage or intravenous if not improving. See your primary doctor as he/she will follow your cultures or recommend the next part of your care. Be well and tell your pharmacist about reaction to bactrim (sulfamethoxazole and trimethoprim).