Could you tell me what's the best safe ways to deal with major depression?

Encourage you to: Start by seeing your physician. Your doctor can not only assess for a mood disorder but can also check for underlying medical conditions that may be the cause of your depressive symptoms. Talking therapy (such as cognitive behavioral therapy or insight oriented psychotherapy) is extremely important for lasting change. Psychiatric medications may be indicated. Don't isolate. Spend time w people. >.