I have been lethargic and generally unwell with constant headaches for two months. blood test show raised crp, esr and positive for ana. what's wrong?

Auto immune disorder: Need further detailed evaluation for auto immune diseases based on limited information you have provided . Thorough evaluation by a rheumatologist would help define the problems with appropriate treatment.

Rheumatologic eval: This requires rheumatologic evaluation. ANA can be positive with diseases other than lupus, but inflammatory processes and lyme disease of course need to be assessed.