What do you suggest to beat genetic disposition to obesity?

Reduce weight: Having a genetic predisposition to obesity just means you'll have to work a little harder. Start by changing your lifestyle to a healthier one. You don't need a drastic diet. Make small changes. Eat the right portions, eat 3-5 small meals a day, cut back on carbs and sugars, increase lean protein/veggie/fruit/water intake, and start doing cardiovascular exercise routinely.