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A 44-year-old male asked:

My daughter was diagnosed with t cell all last year.her karyotyping :abnormality in t(11;14)(p13;q11.2). is there a targetted therapy for lmo2 issues?

2 doctor answers5 doctors weighed in
Dr. Ashu Syal
Pediatric Nephrology and Dialysis 30 years experience
Not yet: Gamma c gene inserted in scid patients; could cure the immune deficiency. But the two, gamma c gene was inserted close to lmo2 gene ( considered oncogene) which gets activated with gamma c gene insertion - causing increased proliferation on t cells ( causing t cell leukemia). Studies/ research on its way to target lmo2 gene.
Dr. Michael Engel
Pediatric Hematology and Oncology 20 years experience
Unfortunately, No: The t(11;14)(p11, q13.2) translocation places the lmo2 gene under the control of the t-cell receptor promoter, driving lmo2 protein expression. Lmo2 regulates the functions of transcription factors that regulate cell fate specification like tal1 (itself frequently mutated in t-all) e2a and gata1. Essentially it acts as a scaffold for assembling a multi-protein complex that control gee expression.

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Last updated Nov 28, 2017

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