Taking into consideration diagnoses of - bilateral perisylvian polymicrogyria, closed-lip schizencephaly, and an absent septum pellucidum - if the mri report states "grossly normal-appearing pituitary and optic pathway" would you investigate further?

Your post needs to provide more information so we can understand what you mean by investigating further. You fail to cite the patients age or other data. The label describes a severe defect of the brain which may be associated with chromosomal defects.

In spite of your vague and nonspecific post, would interpret this to describe a baby, born with a number of significant brain abnormalities. Recommend working with a geneticist, and a pediatric neurologist. Case management will be complex and challenging.