Persistent diarrhea 6-8+/day and it wakes me at night, fatigue, lower abdominal pain left and right side, abdominal distention, blood/mucus in stools. numbness in hands and feet. crp 1.2, esr 93, rbc 3.47, bun creat 60. gi doc said ibs. misdiagnosis?

A GI doc is less likely to have misdiagnosis of IBS, however second opinion is not bad but not possible without comprehensive evaluation of history and other information. What is more important is for you to implement management techniques to curb the disease state. Cognitively managing the symptoms and electrolyte disturbance and meds as prescribed should improve symptoms making it easier for you

Some of your symptoms are not typically seen in irritable bowel and an ESR of 93 is abnormal suggesting an inflammatory condition. If at some point in the past you have been diagnosed with irritable bowel, current symptoms and blood work suggest an additional condition that will need proper work up. Keep your primary care doc involved, follow up with your gi doc.