Can i take 25mg of benadryl with 2 , 5/325mg hydrocodone?

It may increase your sleepiness but otherwise it is OK. Good Luck

Not enough in the question for a meaningful answer. In general try to take meds as prescribed, self medicating may create problems, best to answer your question is your current prescriber.

You may take both medications together, however, both Benadryl and hydrocodone can make you drowsy, dizzy, confused, or lightheaded. So taking both will increase the likelihood of experiencing those side effects. The first time you take both, do it at a time when you won’t be driving or operating heavy machinery for the rest of the day or until you know how it affects you.