Totally different: Benadryl (diphenhydramine) is an antihistamine and hydrocodone is an analgesic. Benadryl (diphenhydramine) works for allergic diseases , hydrocodone works for certain pain. However I believe you meant hydrocortisone cream which works for allergic skin lesions (contact dermatitis) since I am unaware of the availability of a hydrocodone cream.
Answered 6/24/2015
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