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A member asked:
I know renal adjustment doses are necessary for certain medicine regimens in people with renal disease; but are renal adjustments needed for a single dose of medicines? in this case, 800mg cefixime single dose for gonorrhea (ceftriaxone unavailable?
A doctor has provided 1 answer
In general for patient with advance kidney disease there is no need for dose adjustment with a single dose unless you want to avoid the exposure time. Certain antibiotic needs an appropriate peak level for its effectiveness so you need the full dose and it is not harmful to the kidney function if cefixime lasts a little bit longer in case of renal insufficiency.
Answered 12/8/2021
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