What is the significance of a positive ana test that found a dense fine speckled pattern at a titer of 1:1280 and also found a cytoplasmic reticular/ama pattern at 1:40? i have an appointment with a rheumatologist but cant get in until march?

Autoimmune disorder: You have an autoimmune process but these tests have to be interpreted in the light of clinical symptoms and findings. You don't mention your symptoms. AMA antibodies are directed primarily to the liver. If I were you I would look for another rheumatolgy practice in order to obtain a much earlier appointment. Try a rheumatology department at a university hospital near you.

A positive ANA, even at high titer, is typically of no significance unless there are signs and symptoms such as rashes, joint swelling, significant weight loss and persistent fevers. The ANA may be drawn for new onset anemia or kidney disease. False positive ANA are very, very common. As many as 5 out of 100 well people will have a positive ANA and remain quite well. Good luck!