A 42-year-old female asked:
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can letrozole suppress estrogen to where it is undetected and increase fsh to over 60. always ovulate, no hx of spotting until i took femara for iui. doc tested cd 10 (3 days after last dose), said e2 0 and fsh over 60. ?

1 doctor answer
Dr. Ralph Boling
39 years experience Obstetrics and Gynecology
Unlikely to be just : femara, more likely perimenopause, premature menopause. Femara suppresses conversion of androgens to estrone, not a direct estrogen suppressor. Should allow normal FSH/estrogen process to allow ovulation to proceed. The androgen/estrone suppresses ovulation while it is present, typically from polycystic ovarian syndrome.
Answered on Feb 24, 2020
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