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I have been diagnosed with IGM Kappa Mgus when I turned 35. Spike 2g/dl. No other problem and bone marrow biopsy clean. What is risk of progression?
Is elevated kappa/lambda ratio on serum FLC test inherently monoclonal, even if neither kappa or lambda is elevated? Ratio high b/c lambda is low, not because of high kappa. SPEP/UPEP & IFE normal. High IgA, low IgG. Clean marrow biopsy. Polyclonal?
If bone marrow aspirate results are reported as 10% plasma cells, does that mean smouldering myeloma? Is the core biopsy plasma cell % likely to be higher? I have an m-spike of 11.4 g/l IGA LAMBDA, low IGG and IGM. Am I in for scans next?
Free kappa light chain is high, FLC ratio is 2.205, no monoclonal gammopathy. IgA 389.43, lgM 125.95 and lgG 1771.02 H. Should we be worried? Thanks.
Although there is kappa predominance of CD19-negative plasma cells by flow cytometry, morphologic features do not permit diagnosis of plasma cell neoplasm --Can you interpret this to me, please? Is this MGUS, SMM or MM? It is part of my BM biopsy?
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