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A 65-year-old male asked:

I have a psa done once each year. along with various other blood tests, this is purely a routine check. however, as a matter of interest, is it true that the psa level never falls if a person has prostate cancer?

3 doctor answers5 doctors weighed in
Dr. Gregory Lewis
Urology 44 years experience
See below. : IF an elevated PSA is due to prostate cancer, then in the absence of treatment, one would not expect a significant, reproducible decline keeping in mind that there can be PSA variations within the body of 10-20%; not uncommon to have variations both within a specific lab and/or between different labs; and that one can have prostate cancer with PSA variations occurring for unrelated reasons.
Dr. Gurmukh Singh
Pathology 49 years experience
Never say never: If there is an infarct in the gland and cancer, the PSA level may rise temporarily and then drop to the baseline level, which may be a high level in itself. Wish you good health!
Dr. Silviu Pasniciuc
Internal Medicine 27 years experience
Not true: PSA does fall if treatment ( for prostate cancer) is working, it might never be in normal range, but I have seen cases where it went from 3 digits( hundreds) to 1 digit (6-7) if the treatment works. PSA is otherwise no longer recommended to be checked yearly routinely for patients that are otherwise low risk for prostate cancer.

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Last updated Jun 19, 2018

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