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Saint Charles, MO
A 24-year-old female asked:

is it possible for serotonin toxicity to develop from intense exercise while on 90mg duloxetine? started exercising this week and feel like i did when i had serotonin syndrome in the past.

2 doctor answers2 doctors weighed in
Dr. Jack Tseng
Family Medicine 9 years experience
Likely drug combo: If indeed you are experiencing serotonin syndrome as previously diagnosed, it is most likely is due to the combination of medication you have listed. Trazodone blocks the re-uptake of serotonin and the combination with duloxetine increases the likely hood of serotonin syndrome. In addition, there have been reported cases as well with Concerta. This can be deadly. Contact your doctor ASAP.
Dr. Stuart Hickerson
Family Medicine 32 years experience
Rhabdo: Possible. Dloxetine is associated with rhabdomyolisi. The exercise could be a factor here. I would talk to your provider.

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Last updated Jul 17, 2017

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