A member asked:

Is it possible for serotonin toxicity to develop from intense exercise while on 90mg duloxetine? started exercising this week and feel like i did when i had serotonin syndrome in the past.

2 doctors weighed in across 2 answers
Dr. Jack Tseng answered

Specializes in Family Medicine

Likely drug combo: If indeed you are experiencing serotonin syndrome as previously diagnosed, it is most likely is due to the combination of medication you have listed. Trazodone blocks the re-uptake of serotonin and the combination with duloxetine increases the likely hood of serotonin syndrome. In addition, there have been reported cases as well with Concerta. This can be deadly. Contact your doctor ASAP.

Answered 7/1/2017

639 views

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Dr. Stuart Hickerson answered

Specializes in Family Medicine

Rhabdo: Possible. Dloxetine is associated with rhabdomyolisi. The exercise could be a factor here. I would talk to your provider.

Answered 7/17/2017

617 views

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