Hx invasive lobular ca 2006, now hard painful spot on skull, hypercalcemia, anemia & tumor markers elevated after stable for years. what could it be?

Needs quick attentio: If you have anemia(?Hb level) and high Calcium, you must have a check up and further evaluation to make sure that the cause of these abnormal tests is found quickly. Breast cancer can come back and often relapses into Bone/s. So your painful spot on the skull worries me. A Bone scan is a good test to check your bones, to start with.