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A 31-year-old male asked:

Possible to have an autoimmune disease w/ very low c-reactive protein & esr/sed rate? ana is negative, but doc said he thinks i have something autoimmune going on. i always thought autoimmune diseases were inherently inflammatory in nature?

2 doctor answers2 doctors weighed in
Dr. Richard Zimon
Internal Medicine 59 years experience
Yes: for example TYPE 1 DIABETES is thought to be an autoimmune disease and it is not accompanied by the usual inflammation markers! Another example is Pernicious anemia. Hope this is helpfu; Dr Z
Dr. PHILIP WALLER
Rheumatology 33 years experience
Yes and No: You are correct that we lump autoimmune and inflammation together. The problem with autoimmune labs is they can change almost day to day. There are certainly more tests then an ANA that can be positive even in light of a negative ANA. A good history and physical exam are more important then labs even though labs and xrays can be helpful and supportive of a diagnosis. Your doctor may be correct

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Last updated Feb 19, 2017

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