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A member asked:
Possible to have an autoimmune disease w/ very low c-reactive protein & esr/sed rate? ana is negative, but doc said he thinks i have something autoimmune going on. i always thought autoimmune diseases were inherently inflammatory in nature?
2 doctors weighed in across 2 answers
Yes: for example TYPE 1 DIABETES is thought to be an autoimmune disease and it is not accompanied by the usual inflammation markers! Another example is Pernicious anemia. Hope this is helpfu; Dr Z
Answered 2/18/2017
794 views
Yes and No: You are correct that we lump autoimmune and inflammation together. The problem with autoimmune labs is they can change almost day to day. There are certainly more tests then an ANA that can be positive even in light of a negative ANA. A good history and physical exam are more important then labs even though labs and xrays can be helpful and supportive of a diagnosis. Your doctor may be correct
Answered 2/19/2017
793 views
Related Questions
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41 year old female, severe stiffness and joint pain that comes and goes. Ana, ccp, and RH factor all normal. CRP 30 and ESR 77 and anemia. Possibility of an autoimmune disorder?
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