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Greeley, CO
A 55-year-old female asked:

Can you take melatonin at the same time as benadryl (diphenhydramine)? i take benadryl (diphenhydramine) for allergies but im still having trouble sleeping, dont want to mix what i cant.

1 doctor answer2 doctors weighed in
Dr. Linda Schwartz
Pharmacology 18 years experience
Melatonin &Benadryl: You can take both melatonin and benadryl (diphenhydramine) together. They have different mechanisms of actions. However, they will have a synergistic effect (more sedation, drowsiness). Avoid alcohol and driving. Tips to help with sleep. Avoid stimulants (i.e., caffeine). Get plenty of exercise. Avoid late eating. Make sleep environment relaxing (no reading, no tv).
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Last updated Jul 14, 2016

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