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A 31-year-old male asked:

Significance of mildly low igg(691; 700-1600) & mildly high iga(400; 90-386)? igm ok. no monoclonal protein on serum electropho/immunofix & not getting sick more often. am i immunocompromised? will rabies vaccine fail? titer >.5 iu/ml in oct 2015.

2 doctor answers4 doctors weighed in
Dr. John Chiu
Allergy and Immunology 58 years experience
Uncertain: If you have a borderline low IgG but otherwise have no problem with infections (sinus and lungs usually) or other symptoms, just monitoring once yearly would be enough. More important is how your body responds to infection post-vaccination in determining whether you have an impaired immune system or not Consult an allergist/immunologist if you suffer from frequent infections.
Dr. Christine Hom
Pediatrics 31 years experience
Blood tests: There are a few diseases that leap out from blood tests. Most of the time, however, blood tests don't tell the doctor much on their own. These results fall into the second group, not very specific. Your remark that you are not getting sick more often is the best indication that your immune system is working well.

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