A member asked:

Could one become toxic from taking 0.6 mg of colchicine twice daily 12 hrs apart.

2 doctors weighed in across 2 answers

No: That dose is quite safe. One could have side-effects such as diarrhea but one would not become "toxic."

Answered 2/28/2016

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Dr. Charles Turck answered

Specializes in Pharmacology

Possible: Colchicine’s primarily affects the stomach and gut - its effects are diarrhea, as well as nausea and vomiting. Your question is a good one; the recommended dose for gout prophylaxis is 0.6 mg twice daily 12 hours apart. Many different patients respond differently to colchicine - some are very sensitive and experience diarrhea after one or two doses, some can tolerate many.

Answered 3/1/2016

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