Morning hp 120/80 but goes up to 185/85 just after taking bystolic (nebivolol) or isosorbide and stays for an hour. on 5 mg pred/arb in pm/no issues. adh issue?

No, isosorbide: B"sd Amazing occurence. Bystolic (nebivolol) is a balanced blocker with both beta and some alpha blocking - not likely the cause. Isosorbide is a vasodialator and in fact has been reported as a cause of paradoxical hypertension. See: http://www.ncbi.nlm.nih.gov/pubmed/9752888 Would consult with your cardiologist, as to relevance of this possibility in your case.