A member asked:

Can using 0.3ml lidocaine with 1:100, 000 epinephrine during dental work interacts with bystolic, (nebivolol) benicar/hct or isosorbide mononitrate medicine.?

11 doctors weighed in across 3 answers

Insignificant: At concentrations given above it does not matter. There is no known contraindication on concurrent use of the above mentioned drugs.

Answered 5/28/2016

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Dr. J. Blake Perkins answered

Specializes in Dentistry

Probably not: Although Lidocaine is a vasodilator, there is no clinical evidence of any drug interactions or special precautions needed. However, if during the injection, some of the anesthetic were to be introduced directly into a blood vessel, the Epinephrine could cause a minor and short acting increase in heart rate.

Answered 1/14/2015

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Dr. Paul Grin answered

Specializes in Pain Management

Definitely, no: There is no drug interaction between these medications.

Answered 10/31/2014

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