Can using 0.3ml lidocaine with 1:100, 000 epinephrine during dental work interacts with bystolic, (nebivolol) benicar/hct or isosorbide mononitrate medicine.?

Insignificant: At concentrations given above it does not matter. There is no known contraindication on concurrent use of the above mentioned drugs.

Probably not: Although Lidocaine is a vasodilator, there is no clinical evidence of any drug interactions or special precautions needed. However, if during the injection, some of the anesthetic were to be introduced directly into a blood vessel, the Epinephrine could cause a minor and short acting increase in heart rate.

Definitely, no: There is no drug interaction between these medications.