Can bystolic (nebivolol) cause depression as some other beta blockers can?

Depression and meds: Reportedly, some people taking Bystolic (nebivolol) have avoided developing symptoms associated with depression. However, many other factors may contribute to someone developing depression symptoms while on any medication. If Depression symptoms occur, contact your doctor.

Depression & BB.: Depression due to beta-blockers is related to the lipid-solubility of the medication - some can get into the central nervous system more easily than others, thereby causing depression. So while the intensity of the effect varies among the medications, beta-blockers in general are linked to causing depression.