Is it safe to take melatonin at night if i take 5-htp and valerian root during the day?

Melatonin . . .: this is perfectly fine for you to try at night. Your real question pertains to potential drug interactions. Drug interactions are both studied and recorded for prescription medications. This knowledge is very important to us as physicians, when we are writing multiple prescriptions. However, there is significantly less data available on how one OTC medication/supplement might interact with another