A member asked:

I have addisons disease. they want me on prednisone of hydrocortisone. which one has less negative side effects? thanks

A doctor has provided 1 answer
Dr. Paul Kaplowitz answered

Specializes in Pediatric Endocrinology

Either should be OK: If the dose is adjusted properly, either hydrocortisone or prednisone can be used for Addison's disease, keeping in mind that prednisone is about 5 times as potent. Prednisone has the advantage of a longer half life so twice a day works well. For hydrocortisone, some people need to take it 3 times a day to avoid having symptoms of fatigue for part of the day.

Answered 7/26/2020

2.8k views

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