A member asked:

What are the differences between cortef (hydrocortisone) and prednisone in terms of replacing natural cortisol. other than the potency. ?

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Dr. Aaron Pardini answered

Prednisone vs HC: The biggest difference between Hydrocortisone (cortef) and Prednisone is the amount of time they stay in yor bloodstream or half life. Prednisone has a longer half life then Hydrocortisone and is give once a day vs twice a day with hydrocortisone. Hydrortisone is usually the preferred steroid to treat cortisol deficiency because it more closely reproduces the diurnal variation of cortisol producti.

Answered 6/30/2014

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A member asked:

What are the differences between cortef (hydrocortisone) and prednisone in terms of replacing natural cortisol. other than the potency. ?

A doctor has provided 1 answer

Dr. Aaron Pardini answered

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