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A 34-year-old male asked:

Doc just switched me from 60mg prozac to 200 zoloft (sertraline). no taper of pz, no titration to 200mg of zoloft (sertraline). stop p one day, start 200mg z the next. ok safe?

2 doctor answers4 doctors weighed in
Dr. Jeffrey Satinover
Psychiatry 39 years experience
To think about:: Prozac (fluoxetine) leaves the body very slowly, so adding another SSRI at an equivalent dose is like doubling it for awhile. Here are some Canadian guidelines worth a discussion http://www.bcguidelines.ca/pdf/depress_appd.pdf
Dr. Susan Rhoads
Family Medicine 38 years experience
Great information! However, copy and paste the link in another browser window. Using the Healthtap site as proxy link will not take you to the right page, because it filters out pdf and some other extensions.
Jun 22, 2016
Dr. Susan Rhoads
Family Medicine 38 years experience
Oops. That link does not work in another browser. The topic of major depression is this page: http://www2.gov.bc.ca/gov/content/health/practitioner-professional-resources/bc-guidelines/depression-in-adults
Jun 22, 2016
Dr. Susan Rhoads
Family Medicine 38 years experience
Jun 22, 2016
Dr. Alan Ali
Dr. Alan Alianswered
Psychiatry 32 years experience
Prozac/Zoloft: Stopping Prozac is not a problem, but starting Zoloft (sertraline) at lower dose then gradually increasing dose as tolerated, would be my advise. Please consult your prescribing doctor first.

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Last updated Dec 24, 2020

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