A member asked:

Doc just switched me from 60mg prozac to 200 zoloft (sertraline). no taper of pz, no titration to 200mg of zoloft (sertraline). stop p one day, start 200mg z the next. ok safe?

4 doctors weighed in across 2 answers
Dr. Jeffrey Satinover answered

Specializes in Psychiatry

To think about:: Prozac (fluoxetine) leaves the body very slowly, so adding another SSRI at an equivalent dose is like doubling it for awhile. Here are some Canadian guidelines worth a discussion http://www.bcguidelines.ca/pdf/depress_appd.pdf

Answered 6/22/2016

3.1k views

Thank
Dr. Alan Ali answered

Specializes in Psychiatry

Prozac/Zoloft: Stopping Prozac is not a problem, but starting Zoloft (sertraline) at lower dose then gradually increasing dose as tolerated, would be my advise. Please consult your prescribing doctor first.

Answered 12/24/2020

3.1k views

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