I suffer with crippling depression and anxiety . i take prozac & have tried lex, cit, zoloft (sertraline) etc & none really help. no one understands. what do i do?

Get therapy also: Are you being prescribed these medications by your primary care physician, or a psychiatrist? Medications are only part of treating depression/anxiety, and psychotherapy is essential. Some psychiatrists do both, but more often people work concurrently with a psychologist or other therapist. If you haven't already, you might see a psychiatrist -- could be more helpful, esp in complex cases.

Get additional help: It sounds like you have tried several medications. However, there are several you have not tried. You may benefit from a stronger medication such as a monoamine oxidase inhibitor, mood stabilizer or atypical antipsychotic. There needs to be a more aggressive diagnostic work up in your case. Therapy can likely help. Talk with your psychiatrist about the next step!