Calcification of the bladder is it cause for worry?

Absolutely because: the urinary bladder's role is to be a distensible bag which collapses to less than 5 cc yet able to expand to several hundred cc of urine. Calcium in walls reduces tissue flexibility plus there must be marked ongoing wall damage to result in this calcification response to the point it can be detected, reflecting a significant ongoing internal body destructive behavior, on whatever basis.