Can i take mdma with ssris?

I wouldn't take MDMA: for any reason, because its really bad for your brain cells. It would not primarily target most of the same neurotransmitters as Prozac (fluoxetine), (fluoxetine) but the crash afterwards would certainly be in the wrong direction. Prozac (fluoxetine) is an anti-depressant with some anti-anxiety properties. Why would you want to take something that would likely cause you MORE depression afterwards?

Agree w Dr. Griggs: Don't do it. MDMA has many potential adverse effects to include: irritability, aggression, ^ in impulsivity,anxiety, low mood, sleep problems, low appetite, V sex drive & pleasure,^ blood pressure, cardiac arrythmia, ^ body temperature, muscle cramps, dehydration, chills, sweats, visual changes as well as renal or heart failure.