Is there a washout period to get other multiple sclerosis meds out of the system before starting tecfidera (bg12)?

Unlikely: Given how bg12 works, it is unlikely that a washout period is needed. There is nothing in the package insert about a washout. I am not certain if one is on an immune modulator ala tysabri (natalizumab) if a washout is indicated, but it is doubtful that one is needed for the typical abcr medicines.

Multiple sclerosis: This is very good question as no data is available to respond to it.When switching from interferon beta1a (im/sq) or beta 1b, and glatiramer no wash out appears to be necessary. A switch from Gilenya may require a longer period of time. For tysabri, (natalizumab) as the effect in the csf/cns lasts 6 months, i would wait at least this long before starting a new agent. Teriflunamide washout may be the longest.

Do NOT recommend: Many neurologists are fearful that stopping Tysabri (natalizumab) and starting a new agent prior to 3 months could be a risk for PML, but waiting too long can result in relapse or even severe rebound. Am not really using much of a washout with any of the drugs, including Aubagio as reality far outways fears of the unknown. Stop your current agent, and go onto Tecfidera 120 mg twice daily tomorrow.