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A member asked:
What is significance of ana of 1:640 vs 1:320or 1:80.i know what the dilution means, but does higher titer even make a difference in clinical picture?
6 doctors weighed in across 3 answers
ANA titers important: Here is a wonderful description of what the test measures: http://labtestsonline.Org/understanding/analytes/ana/tab/test. "also, ANA may become positive before signs and symptoms of an autoimmune disease develop, so it may take time to tell the meaning of a positive ANA in a person who does not have symptoms.".
Answered 6/10/2014
5.2k views
No: The level of the ANA titer does not correlate with disease severity or activity.
Answered 6/10/2014
5.2k views
ANA titer matters.: ANA, or anti-nuclear antibody, is a a sensitive and specific test for systemic lupus erythematosus ONLY at high titer >1:320. Up to one in ten HEALTHY women can have a positive low-titer ANA, 1:40 or 1:80, which does NOT indicate lupus. Only a high-titer ANA can be used to diagnose lupus. To measure clinical activity in lupus, a different antibody called anti-double stranded DNA is measured.
Answered 5/8/2016
3.5k views
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