A member asked:

Will a multivitamin containing 400 mcg of folic acid interfere with the efficacy of l-methylfolate as an ssri adjunct for a homozygous tt mthfr?

A doctor has provided 1 answer
Dr. Robert Olsen answered

Specializes in Psychiatry

Not at all: The homozygous mthfr mutation limits your cells' ability to activate the dietary Folic Acid and the Folic Acid in the multivit. The l-methylfolate is the active form of Folic Acid and can go right to work improving your neurotransmitter synthesis. But the mthfr mutations may also interfere with your complete utilization b12, ask you doctor if you need active b12, methylcobalamin, as well.

Answered 4/17/2016

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