A member asked:

I am pregnant and have a mthfr gene mutation and i recently read that folic acid is not good for me or the baby and i should take folate instead?

5 doctors weighed in across 3 answers

Folic acid is folate (folic acid): Folic acid and folate are the same compound. Follow your gynecologists and hematologists recommendations. Folate is often prescribed during pregnancy in the field of psychiatry and neurology when patients are on anticonvulsants. I too have the same mutation that you have and i take folate every day. I have also been advised to take vitamin b6 and vitamin b 12 because of this. Your child should also be tested for this mutation and anyone else in your family.Best wishes.

Answered 11/26/2017

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Dr. Pamela Pappas answered

Specializes in Psychiatry

MTHFR: If you've been tested for mthfr mutations and do have one, then your body may not do well with Folic Acid at all. You would benefit more from methylfolate since it bypasses the metabolic step that your system has trouble with. You need a functional medicine or integrative medicine doc who really knows mutations in this enzyme ; can advise you plus collaborate with your ob-gyn doc too.

Answered 11/26/2017

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Dr. Su Fairchild answered

Specializes in Integrative Medicine

Folic acid is bad: Folic acid is synthetic folate, and needs extra metabolic steps to turn it into a usable form. The body is very slow to convert it, and unmetabolized folic acid downregulates your folate receptors and folate binding proteins. This is a bad thing. Avoid folic acid, and take methylfolate instead.

Answered 11/26/2017

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