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A member asked:
I'm on 12.5 mg methotrexate week. take in pm.next day my brain feels fried &i'm so tired i find myself making silly errors at work! will this go away?
3 doctors weighed in across 2 answers
Possibly: Methotrexate, when given intravenously or in high doses, can irritate nerve cells in the peripheral and central nervous systems. There is not much data about small oral doses and cognition. When chemotherapies affect the peripheral system, vitamin e and acetyl L-carnitine have been effective in alleviating symptoms and helping nerve cells heal. It would not be illogical or unsafe to try them.
Answered 5/21/2016
5.3k views
Divide the dose: If you divide the dose over a 48 hour period, these symptoms may disappear.
Answered 2/14/2013
5.3k views
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