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A member asked:
Does dividing subcutaneous 12.5 mg methotrexate dose into am and pm dose lose its effectiveness? can it help reduce that terrible brain fatigue?
A doctor has provided 1 answer
PROBABLY NOT: Have used the drug once weekly, and also, at other infrequent intervals. Taking it more frequently is unlikely to compromise efficacy. However, you mention fatigue, and not clear to me why you are taking methotrexate, or what is your underlying mechanism for fatigue. So, cannot answer that until more info.
Answered 2/27/2013
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