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A 23-year-old male asked:

Help! i know they say don't come off of depakote urself but i have heard a lot say there were no side effects for them doing so. i also take seroquel (quetiapine)?

2 doctor answers6 doctors weighed in
Dr. Steven Reidbord
Psychiatry 37 years experience
Relapse vs withdrawl: While there are usually no side-effects, ie withdrawal, from stopping depakote, there is a very real risk of relapse. That is, the original problem that led to taking Depakote in the first place could return. Since Depakote is used for serious conditions, stopping this treatment without close monitoring by your doctor could be very risky.
Dr. Bennett Machanic
Neurology 53 years experience
Get help: If you wish to stop depakote, do not do it yourself, and there is a significant risk of a seizure if stopped too rapidly. Also, possible withdrawal migraine. Needs to be tapered slowly, under supervision. The seroquel (quetiapine) suggests it was used for mood stabilization, and improper cessation could cause significant emotional problems. See your doctor and work together.
Last updated Jan 5, 2019


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