I'm on 100mg trazodone, 100mg zoloft (sertraline) 1000mg depakote 2mg risperal & seroquel xr 150mg at night. i feel high 30minutes later should this be happening?

No: I would talk to your psychiatrist, i suspect your blood pressure is either getting low on all of that trazodone and quetiapine or you are becoming slightly delirious on the two antipsychotics. If you have one of those battery operated blood pressure cuffs you may want to check your blood pressure about 30 minutes to an hour after you take those medicines if you are even able to stay awake.

No: No, you should not feel "high" after taking your medications. Hopefully you're not adding recreational drugs to this combination. Please call your psychiatrist today about this. It could be the zoloft, (sertraline) which in people with bipolar disorder can trigger mania -- experienced by some as a "high.".

Feeling high on meds: You should report your situation to your doctor to see if you are having an appropriate response to the five very potent medications. Your prescribing doctor that knows you and all the facts is the one to consult about this.

Combo: You are experiencing combined sedative effects of those medications. Talk to your doctor about adjusting doses or timing of taking them.