Can depression and ptsd change your brain structure and cause neurological problems later in life? i am 33 and have been on meds & therapy for 5 yrs.

PTSD & depression: Yes, these conditions can change your brain. And the brain can change. The brain has neuroplasticity, such that forming new neural networks through meditation, psychotherapy, and other ways can aid healing from long-standing modes of seeing the world. More research is accumulating about this. Treatment of ptsd and depression may allow certain brain structures that are smaller, grow normally.

Brain changes: Ptsd can cause significant changes in brain physiology. The amygdala (fight or flight) becomes over -active. The frontal cortex forgets to monitor the amygdala- so there is more impulsive behavior the hippocampus forgets to do it's job laying down new memories and retrieving old ones. Neurotransmitters are out of wack. Early and aggressive treatment is important for optimal outcomes in tx.

Yes: Chronic depression can result in loss of brain volume making mental illness more treatment resistant.