Can antidepressants such as zoloft and wellbutrin (bupropion) cause a flare up of ulcerative colitis?

Little data: Sorry, but there's little available data to answer this question. I found 1 study that tried to review antidepressants in inflammatory bowel disease: http://tinyurl.Com/92lwmmt a couple of the patients did better on wellbutrin -- the authors thought maybe it decreased tumor necrosis factors. 1 patient on Paxil (paroxetine) did have a flare of diarrhea, and several others had less functional disability.

Not known: No one knows what causes uc to flare but there are no reports of antidepressants causing flares.