A member asked:

Can antidepressants such as zoloft and wellbutrin (bupropion) cause a flare up of ulcerative colitis?

10 doctors weighed in across 2 answers
Dr. Pamela Pappas answered

Specializes in Psychiatry

Little data: Sorry, but there's little available data to answer this question. I found 1 study that tried to review antidepressants in inflammatory bowel disease: http://tinyurl.Com/92lwmmt a couple of the patients did better on wellbutrin -- the authors thought maybe it decreased tumor necrosis factors. 1 patient on Paxil (paroxetine) did have a flare of diarrhea, and several others had less functional disability.

Answered 6/30/2014

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Not known: No one knows what causes uc to flare but there are no reports of antidepressants causing flares.

Answered 4/23/2014

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