A 76-year-old male asked:
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Dad has advanced prostate cancer with bone metastasis. After orchirectomy, psa down from 270 to 10. Shall he start zometa or xgeva (denosumab)? Which is better?

1 doctor answer
Dr. Uma Swamy
Dr. Uma Swamy answered
15 years experience in Radiation Oncology
See Below: Use of bisphosphanates for your dad can be controversial. Here is an excerpt from a recent review article on www.cancernetwork.com which you can use to discuss with your father's doctor to decide what is best for your dad. http://www.cancernetwork.com/bone-metastases/content/article/10165/105118.
Answered on Feb 25, 2014
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Dr. James Gulley
25 years experience in Hematology and Oncology
Neither Zoledronate nor denosumab are approved for prostate cancer that has not progressed on the initial hormonal therapy. I would recommend reviewing with the physician the risks and benefits of doing so. In general, I would wait until the PSA starts to progress. And decrease exposure to these drugs that can have side effects.
May 18, 2013

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