U.S. doctors online nowAsk doctors free
NC
A 69-year-old male asked:

dad has advanced prostate cancer with bone metastasis. after orchirectomy, psa down from 270 to 10. shall he start zometa or xgeva (denosumab)? which is better?

4 doctor answers6 doctors weighed in
Dr. Uma Swamy
Dr. Uma Swamy answered
Radiation Oncology 16 years experience
See Below: Use of bisphosphanates for your dad can be controversial. Here is an excerpt from a recent review article on www.cancernetwork.com which you can use to discuss with your father's doctor to decide what is best for your dad. http://www.cancernetwork.com/bone-metastases/content/article/10165/105118.
Dr. James Gulley
Hematology and Oncology 26 years experience
Neither Zoledronate nor denosumab are approved for prostate cancer that has not progressed on the initial hormonal therapy. I would recommend reviewing with the physician the risks and benefits of doing so. In general, I would wait until the PSA starts to progress. And decrease exposure to these drugs that can have side effects.
May 18, 2013
Dr. Julio Hajdenberg
Hematology and Oncology 31 years experience
Either : Xgeva (denosumab) does have some advantages over zometa: quicker administration and no kidney side effects. It is associated with fewer bone complications from cancer than zometa. On the other hand, zometa is now generic, meaning that is a lot cheaper. Neither is a curative treatment for prostate cancer and they are both considered adjunct treatments. Thes small differences may or may not justify its use.
Dr. Richard Sarle
Urology 22 years experience
Bones: Xgeva (denosumab) has less side effect profile in my opinion.
Dr. James Gulley
Hematology and Oncology 26 years experience
Off label: Neither zoledronate nor Denosumab is approved for disease that has not progressed on initial hormonal therapy. I would recommend waiting until disease progression and thus avoid potential side effects from these treatments.

90,000 U.S. doctors in 147 specialties are here to answer your questions or offer you advice, prescriptions, and more. Get help now:

Ask doctors free
Personalized answers
Free
Talk to a doctor
24/7 visits
$15 per month

Related questions

A 31-year-old member asked:
1 doctor answer3 doctors weighed in
A 41-year-old member asked:
2 doctor answers3 doctors weighed in

90,000 U.S. doctors in 147 specialties are here to answer your questions or offer you advice, prescriptions, and more. Get help now:

Ask doctors free
Personalized answers
Free
Talk to a doctor
24/7 visits
$15 per month
Last updated Jun 25, 2014

Disclaimer:

Content on HealthTap (including answers) should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. Never disregard or delay professional medical advice in person because of anything on HealthTap. Call your doctor or 911 if you think you may have a medical emergency.