A 69-year-old male asked:
dad has advanced prostate cancer with bone metastasis. after orchirectomy, psa down from 270 to 10. shall he start zometa or xgeva (denosumab)? which is better?
4 doctor answers • 6 doctors weighed in
Radiation Oncology 16 years experience
5378 viewsReviewed >2 years ago
Hematology and Oncology 31 years experience
Either : Xgeva (denosumab) does have some advantages over zometa: quicker administration and no kidney side effects. It is associated with fewer bone complications from cancer than zometa. On the other hand, zometa is now generic, meaning that is a lot cheaper. Neither is a curative treatment for prostate cancer and they are both considered adjunct treatments. Thes small differences may or may not justify its use.
5376 viewsAnswered >2 years ago
Urology 22 years experience
Bones: Xgeva (denosumab) has less side effect profile in my opinion.
5198 viewsReviewed >2 years ago
Hematology and Oncology 26 years experience
Off label: Neither zoledronate nor Denosumab is approved for disease that has not progressed on initial hormonal therapy. I would recommend waiting until disease progression and thus avoid potential side effects from these treatments.
5110 viewsAnswered >2 years ago
Last updated Jun 25, 2014
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