A member asked:

Why does a long half-life mean a long withdrawal? xanax (alprazolam) and oxycodone have short hls but w/d can last months. why would suboxone. be longer?

9 doctors weighed in across 2 answers
Dr. James Henning answered

Specializes in Anesthesiology

Narcotic withdrawal times and severity are complex phenomena and not easy to summarize. The time it takes the body to get rid of narcotics (half-lives) may have far more to do with length and severity of dependence, malnutrition, sleep deprivation and kidney and liver function than the pharmacokinetic profile of the drug. Please speak with your pain management specialist for specific advice.

Answered May 5, 2016


Dr. David Simons answered

Specializes in Anesthesiology

Suboxone withdrawal is usually over in 7 days however some symptoms may persist for a month or two. Physician supervision during this process is essential.

Answered Mar 6, 2019



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