A member asked:

Had 5 ana +reflex labs within 1 year. three came back elevated (one very high) 2 normal. any particular reason for the fluctuation?

A doctor has provided 1 answer
Dr. Thomas Namey answered

Specializes in Rheumatology

No correlation!: Anas do not correlate with disease activity. The only significance of titer is that it is more likely to be a true positive when extremely high.Anas are not followed in lupus, sjogren's, or scleroderma, like the antibbodies more specific for the disease!

Answered 12/9/2013

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