Is it safe to simultaneously take penicillin, ibuprofen and vicodin?

Under doctor's care: It is safe for most people to take these drugs together if under a doctor's care. Only a doctor can determine is this is safe based upon your past health history and current medications.

Assuming no : Allergies, or contraindications on your part, the trio can be taken together, one is an antibiotic, one an antiinflammatory and one a pain killer. A common scenerio might be post-op where a patient happens to have an infection or receiving the tail end of a prophylactic antibiotic.