What is the origin of cancer of colon?

Colon cancer: Genetic alterations (changes in the dna or ways in which dna is regulated) in the epithelium of the colon (the cells that line the colon) are the source of colon cancer. These changes can occur for many reasons, some of which are genetics alone (family predisposition), a combination of genetics and environment (foods, toxins), or the we don't exactly know category.