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Middletown, NY
A 56-year-old female asked:

I have crohn's and have been on pentasa, (mesalamine) humira and imuran which severely increase my liver enzymes. would remicade be less liver toxic then imuran?

2 doctor answers3 doctors weighed in
Dr. Arthur Heller
Gastroenterology 44 years experience
Remicade/humira: Remicade (infliximab) and Humira same class: biologics. Imuran (azathioprine) and Purinethol (6 mercaptopurine) same class: immunomodulators. All can affect liver chem, as can crohn's. Ask your doc.
Created for people with ongoing healthcare needs but benefits everyone.
Dr. Thomas Namey
Rheumatology 49 years experience
Several issues!: Humira and Remicade (infliximab) should not be used together. Although they work differently, there net effect is to inhibit tnf-a, a potent mediator of inflammation. Imuran is the most liekly agent to increase lfts, crohn's itself can do this. If you want off the imuran, ciprofloxin and/or metronidazone are options to combine with humira. Do you have arthritis with your crohn's? 30% do.
Created for people with ongoing healthcare needs but benefits everyone.
Last updated Jun 30, 2014

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