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A member asked:

my sister just diagnosis with grade 3 endometrial cancer with clear cells why are clear cells so aggressive?

2 doctor answers4 doctors weighed in
Dr. Michael Swor
Obstetrics and Gynecology 40 years experience
Various cell types: Endometrial cancer is characterized by stage and cell type. Clear cell is a description of the type of cells and simply behave in a more aggressive growth pattern than others.
Dr. Lester Thompson
Pathology 33 years experience
The clear cell doesn't make it more aggressive, but it is a description of the cell type. Endometrial or ovarian cancer when it is poorly differentiated (grade 3) has a more aggressive behavior, made more so when stage is include (extent of disease).
Aug 17, 2012
Dr. John Geisler
Gynecologic Oncology 27 years experience
Endometrial cancer : Clear cell carcinoma of the endometrium is an uncommon, very aggressive variant. It has very different genetic changes in the tumor than does the common endometrial cancer.

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Last updated Nov 24, 2012

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