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A 48-year-old member asked:

have clinical trials ever shown that ldl reduction prevents cad or death?

2 doctor answers2 doctors weighed in
Dr. Gurmukh Singh
Pathology 49 years experience
Yes: Clinical trials with drugs that lower LDL have shown a reduction, not elimination, of cad.
Dr. Milton Alvis, jr
Preventive Medicine 41 years experience
Yes, essentiall ALL: Starting with trials in the early 1970s & becoming far more dramatic since 1995 (4-s trial using zocor (simvastatin) was reported 1995), essentially all clinical trials showing reduction of either LDL particles (most reliable, see: NMR particle test) or estimated ldl-cholesterol, have shown reductions in all cause mortality, mostly due to cv events plus a trend to lower cancer rates. >30 human clinical trials.

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Last updated Jun 10, 2014

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